Shetty V P, Uplekar M W, Antia N H
Foundation for Medical Research, R. G. Thadani Marg, Bombay, India.
Lepr Rev. 1996 Dec;67(4):280-6. doi: 10.5935/0305-7518.19960028.
Skin biopsy homogenates obtained from three cases of lepromatous leprosy with no prior history of antileprosy treatment were tested in the mouse footpad for the sensitivity of Mycobacterium leprae to multiple drugs. One of the inocula was sensitive to all the three drugs tested using the highest concentration each of DDS 0.01 g%, RFP 0.03 g% and CLF 0.01 g%. The 2nd inocula showed growth in the presence of 0.01 g% DDS only. While the 3rd inocula (Pt. KU) tested resistant to all the three drugs in the first, i.e. man to mouse, as well as in the second passage, i.e. mouse to mouse.
从3例无抗麻风治疗史的瘤型麻风患者获取的皮肤活检匀浆，在小鼠足垫中检测麻风分枝杆菌对多种药物的敏感性。其中一份接种物对所测试的全部三种药物敏感，所使用的每种药物的最高浓度分别为：氨苯砜0.01 g%、利福平0.03 g%和氯法齐明0.01 g%。第二份接种物仅在0.01 g%氨苯砜存在的情况下生长。而第三份接种物（患者KU）在第一次即人传小鼠以及第二次传代即小鼠传小鼠过程中，对所有三种药物均耐药。
