Bezon E, Mondine P, Karaterki A, Barra J A
Service de Chirurgie cardiaque, thoracique et vasculaire, CHU La Cavale Blanche, Brest.
Ann Cardiol Angeiol (Paris). 1996 Nov;45(9):495-502.
Retrograde cardioplegia is still controversial due to the heterogeneous left ventricular flow distribution particularly in the posterior wall. The purpose of this study was to compare retrograde flow distribution delivered through the coronary sinus with two types of cannula. Fifty two patients were prospectively randomized to receive cold blood retrograde cardioplegia with manual inflating long balloon prototype cannula (group I, 26 patients) or with manual inflating short balloon cannula (group II, 26 patients). Left ventricular distribution of the cardioplegic solution was assessed by monitoring the left ventricular wall temperatures (anterior and posterior). The cardioplegic retrograde infusion was stopped as the anterior wall temperature reached 15 degrees C. In group I, 91% of the patients had identical cooling in the anterior and posterior wall of the left ventricle, versus 19% in group II (p < 0.05). The mean temperature difference between anterior and posterior wall was 0.5 degrees C (standard deviation = 1.7) in group I versus 8 degrees C (standard deviation = 4.1) in group II (alpha < 0.05). The cannula with the long balloon allows a better left ventricular distribution of the cardioplegia flow than the short one because it occludes the interventricularis posterior vein in the coronary sinus.
逆行性心脏停搏仍存在争议,因为左心室血流分布不均一,尤其是在后壁。本研究的目的是比较通过两种类型的插管经冠状窦输送的逆行血流分布情况。52例患者被前瞻性随机分组,分别接受使用手动充气长球囊原型插管进行冷血逆行性心脏停搏(I组,26例患者)或使用手动充气短球囊插管进行冷血逆行性心脏停搏(II组,26例患者)。通过监测左心室壁温度(前壁和后壁)来评估心脏停搏液在左心室内的分布情况。当前壁温度达到15℃时停止心脏停搏液的逆行输注。在I组中,91%的患者左心室前壁和后壁冷却情况相同,而II组为19%(p<0.05)。I组前壁和后壁的平均温差为0.5℃(标准差=1.7),而II组为8℃(标准差=4.1)(α<0.05)。与短球囊插管相比,长球囊插管能使心脏停搏液在左心室内的分布更好,因为它能闭塞冠状窦内的室间后静脉。