Secchi T, Thomas L, Mathon N, Balme B, Moulin G
Service de Dermatologie, Hôpital de l'Antiquaille, Lyon.
Ann Dermatol Venereol. 1996;123(8):487-9.
We report the first case of bilateral neurofibromatosis localized distally on the lower limbs.
A 36-year-old woman presented about 20 nodular lesions of the plantar and both lateral aspects of both feet which developed progressively after age 30. Histology examination evidenced neurofibromas. Clinical features and laboratory results enabled us to eliminate von Recklinghausen disease in this mother of 3 children.
This observation allowed us to situate symmetrical and bilateral neurofibromatosis in the Riccardi classification for genetic counselling. We conclude that the case was a type V neurofibromatosis in a sporadic bilateral form, rarely reported in the literature.
我们报告首例双侧神经纤维瘤病局限于下肢远端的病例。
一名36岁女性,双足跖面及双侧出现约20个结节性病变,这些病变在30岁以后逐渐出现。组织学检查证实为神经纤维瘤。临床特征和实验室检查结果使我们能够排除这位育有3个孩子的母亲患有冯·雷克林霍增氏病。
该病例使我们能够在里卡尔迪分类法中对对称双侧神经纤维瘤病进行定位,以进行遗传咨询。我们得出结论,该病例为散发双侧型V型神经纤维瘤病,文献中鲜有报道。