de Raucourt E, Vinsonneau C, Juvin K, Fischer A M, Meyer G
Department of Haematology, Laennec Hospital, Paris, France.
Blood Coagul Fibrinolysis. 1996 Nov;7(8):786-8. doi: 10.1097/00001721-199611000-00007.
Heparin-induced thrombocytopenia is very uncommon with low-molecular-weight heparin, especially when given for prophylaxis of venous thromboembolism. In two of the four published cases, with thrombotic complications, thrombocytopenia may have been related to cross-reactivity between unfractionated heparin and low-molecular-weight heparin. We report one patient who received low-molecular-weight heparin for prophylaxis against venous thromboembolism without any previous injection of unfractionated heparin, and experienced thrombocytopenia with thrombotic complications. Heparin-induced thrombocytopenia was confirmed by several laboratory assays. This observation emphasizes the need for platelet count monitoring during low-molecular-weight heparin therapy.
肝素诱导的血小板减少症在使用低分子量肝素时非常罕见，尤其是在用于预防静脉血栓栓塞时。在已发表的4例病例中有2例出现血栓并发症，血小板减少症可能与普通肝素和低分子量肝素之间的交叉反应有关。我们报告1例患者，其在未曾注射过普通肝素的情况下接受低分子量肝素预防静脉血栓栓塞，却出现了血小板减少症并伴有血栓并发症。通过多项实验室检测确诊为肝素诱导的血小板减少症。这一观察结果强调了在低分子量肝素治疗期间监测血小板计数的必要性。
