IgA类风湿因子与类风湿关节炎中B和T淋巴细胞亚群的变化及疾病表现相关。

IgA rheumatoid factor correlates with changes in B and T lymphocyte subsets and disease manifestations in rheumatoid arthritis.

作者信息

Arinbjarnarson S, Jonsson T, Steinsson K, Sigfusson A, Jonsson H, Geirsson A, Thorsteinsson J, Valdimarsson H

机构信息

Department of Immunology, National University Hospital, Reykjavík, Iceland.

出版信息

J Rheumatol. 1997 Feb;24(2):269-74.

PMID:9034982

Abstract

OBJECTIVE

To analyze the relationship between lymphocyte subsets, different rheumatoid factor (RF) isotypes, and clinical features in patients with rheumatoid arthritis (RA).

METHODS

Patients with established RA (n = 95) were examined clinically and blood samples were collected for measurements of RF by ELISA and for analysis of lymphocyte subsets by flow cytometry.

RESULTS

IgA RF positive patients had more severe disease and higher prevalence of extraarticular manifestations than the other patients. Patients with elevated IgA RF had a higher percentage of CD5+ B cells and of CD4+CD45RO+ T cells compared to the other patients with RA or controls. High percentage of CD4+CD45RO+ T cells was also significantly associated with extraarticular manifestations. Patients with the sicca syndrome had significantly higher ratio of CD5+ B cells than patients without or with other types of extraarticular manifestations.

CONCLUSION

Different disease manifestations in RA may be associated not only with certain RF isotypes and RF isotype combinations but also with changes in lymphocyte subsets in the blood. The relative increase of CD4+CD45RO+ T cells in the blood of IgA RF positive patients with RA might reflect preferential recruitment of CD8+CD45RO+ T cells to inflammatory sites.

摘要

目的

分析类风湿关节炎（RA）患者淋巴细胞亚群、不同类风湿因子（RF）同种型与临床特征之间的关系。

方法

对确诊为RA的95例患者进行临床检查，并采集血样，采用酶联免疫吸附测定法（ELISA）检测RF，采用流式细胞术分析淋巴细胞亚群。

结果

与其他患者相比，IgA RF阳性患者的病情更严重，关节外表现的患病率更高。与其他RA患者或对照组相比，IgA RF升高的患者CD5⁺ B细胞和CD4⁺CD45RO⁺ T细胞的百分比更高。CD4⁺CD45RO⁺ T细胞的高百分比也与关节外表现显著相关。与无关节外表现或有其他类型关节外表现的患者相比，干燥综合征患者的CD5⁺ B细胞比例显著更高。