Korin J D, Sánchez Avalos J C
Consultorios de Estudios Hematológicos, Buenos Aires, Argentina.
Medicina (B Aires). 1996;56(3):299-307.
Prevention of venous thromboembolism (VTE) can be achieved through mechanic or pharmacological means. For the latter, unfractionated low dose heparin, low molecular weight heparins and oral anticoagulants are successfully and widely employed. Results of controlled and uncontrolled studies favour the use of prophylactic heparin in different clinical and surgical conditions such as myocardial infarction, stroke, orthopedic or prolonged surgery and surgical interventions in patients older than forty. Useful parameters to evaluate the results of VTE prophylaxis are discussed as well as timing, duration, effectiveness, side effects and costs of therapy. Although the benefits of VTE prophylaxis in high risk patients are clear, it is not routinely employed in Argentina.
静脉血栓栓塞症(VTE)的预防可通过机械或药物手段实现。对于后者,普通低剂量肝素、低分子肝素和口服抗凝剂已得到成功且广泛的应用。对照研究和非对照研究的结果均支持在不同临床和手术情况下使用预防性肝素,如心肌梗死、中风、骨科手术或长时间手术以及对40岁以上患者的手术干预。文中还讨论了评估VTE预防效果的有用参数以及治疗的时机、持续时间、有效性、副作用和成本。尽管VTE预防在高危患者中的益处显而易见,但在阿根廷它并未得到常规应用。