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[切尔诺贝利原子能发电站事故善后清理参与者的免疫系统功能]

[Immune system function in the participants in the cleanup of the aftermath of the accident at the Chernobyl Atomic Electric Power Station].

作者信息

Ivanitskaia N F, Savchenko M V, Sorokina S F, Li Ia B

出版信息

Lik Sprava. 1996 Mar-Apr(3-4):31-3.

PMID:9035874
Abstract

Imbalance was revealed in the proportions of T-lymphocyte subpopulations in those persons engaged in activity in mining employment who had been exposed to a complex of the radiation accident factors. Maximum reduction in the lymphocyte suppressor activity was recordable in those patients in whom the doses of radioactive irradiation received exceeded 25 s Gy. Depression was found of humoral immunity manifested by a drop in the absolute as well as relative numbers of B-lymphocytes and fall in the blood serum levels of Ig G, A. The results of study of clinical-biochemical and immunologic parameters of blood permit individualized therapies be developed, prophylactic measures to be devised to deal with the relevant pathologic processes and conditions in the cohorts examined.

摘要

在那些从事矿业工作且暴露于辐射事故综合因素的人员中,T淋巴细胞亚群比例出现失衡。在那些接受放射性照射剂量超过25 s Gy的患者中,可记录到淋巴细胞抑制活性的最大降低。发现体液免疫受到抑制,表现为B淋巴细胞的绝对数量和相对数量下降以及血清Ig G、A水平降低。对血液临床生化和免疫参数的研究结果有助于制定个体化治疗方案,设计预防措施以应对所检查队列中的相关病理过程和状况。

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