Kelnerić Z, Naglić T, Udovicić I
PLIVA, Pharmaceutical Chemical, Food and Cosmetic Industry, Research Institute, Zagreb, Croatia.
Vet Med (Praha). 1996 Nov;41(11):335-8.
On a large pig farm with a known history of necrotic enteritis 12 pregnant gilts were vaccinated s. c. 7 and 2 weeks before expected farrowing with a commercial bacterin-toxoid preparation of toxigenic strains C. perfringens type C and D (DizevakR-Pliva, Zagreb). At the farrowing the titers of beta-antitoxins in serum samples from vaccinated gilts ranged from 9.0 to 26.0 IU/ml with a mean value of 14.16 IU/ml. Colostral titers varied from 12.0 IU/ml with a mean of 16.12 IU/ml. On the second day of life the mean serum titers between litters differed greatly from 4.75 to 24.0 IU/ml. By the age of 7 days the average serum titers were commonly lower and varied between the litters from 2.25 to 15.0 IU/ml, with a low of 1.5 to a high of 16.0 IU/ml in single animals. Ten (8.47%) out of a total of 118 piglets from vaccinated gilts died during the first 7 days of life but the losses were not caused by C. perfringens infection. In unvaccinated control animals 18 (15.9%) of 113 piglets died, eleven of them with clinical and pathoanatomical signs of necrotic enteritis. The affected piglets predominantly succumbed in the first 4 days of life. These data indicate that the investigated bacterin-toxoid can be successfully used in immunoprophylaxis of necrotic enteritis in piglets.
在一个有坏死性肠炎病史的大型养猪场，12头怀孕的后备母猪在预计分娩前7周和2周经皮下接种了产气荚膜梭菌C型和D型产毒株的商业菌苗-类毒素制剂（DizevakR - Pliva，萨格勒布）。分娩时，接种后备母猪血清样本中β-抗毒素的效价范围为9.0至26.0 IU/ml，平均值为14.16 IU/ml。初乳效价从12.0 IU/ml到平均值16.12 IU/ml不等。出生第二天，各窝仔猪的平均血清效价差异很大，为4.75至24.0 IU/ml。到7日龄时，平均血清效价通常较低，各窝之间在2.25至15.0 IU/ml之间变化，单头仔猪的效价低至1.5 IU/ml，高至16.0 IU/ml。接种后备母猪所产的118头仔猪中有10头（8.47%）在出生后的前7天死亡，但死亡并非由产气荚膜梭菌感染所致。在未接种疫苗的对照动物中，113头仔猪中有18头（15.9%）死亡，其中11头有坏死性肠炎的临床和病理解剖学症状。受影响的仔猪主要在出生后的前4天死亡。这些数据表明，所研究的菌苗-类毒素可成功用于仔猪坏死性肠炎的免疫预防。
