González-Juanatey J R, Pose Reino A, Román A V, García Acuña J M, Fernández López J A, Cerrato J C
Cardiology Department and Hypertension Unit, Complejo Hospitalario Universitario, La Coruna, Spain.
Am J Cardiol. 1997 Feb 1;79(3):373-6. doi: 10.1016/s0002-9149(96)00767-9.
Continued treatment of hypertensive patients with enalapril reduced left ventricular (LV) hypertrophy steadily over a period of 5 years (by which time gross structural parameters were normal) and produced no further reduction during the following 2 years. Temporary suspension of treatment after 5-year follow-up gave rise to an increase in blood pressure, and to deterioration of LV isovolumic relaxation time and deceleration of the ventricular filling E wave, both of which chiefly reflect the active relaxation of the ventricle.
