Centromeric alphoid sequences are breakage prone resulting in pericentromeric inversion heteromorphism of qh region of chromosome 1.
作者信息
Verma R S, Ramesh K H, Mathews T, Kleyman S M, Conte R A
机构信息
Division of Genetics, Long Island College Hospital, Brooklyn, NY 11201, USA.
出版信息
Ann Genet. 1996;39(4):205-8.
PMID:9037348
Abstract
Structural variations in the pericentromeric region of chromosome 1 are considered the norm. We characterized a chromosome 1 with an inversion by FISH-technique and suggested that the origin of pericentromeric heteromorphism is far more complex than previously suggested. It is postulated that similar to the centromeric alphoid DNA sequences of chromosome 9, chromosome 1 also possesses a "breakage prone" centromeric domain which may be a possible cause of such inversions involving the secondary constriction region.
摘要
相似文献
1
2
Pericentromeric heteromorphism of human chromosome 18 as revealed by FISH-technique.
Ann Genet. 1998;41(3):154-6.
3
Structural rearrangements and insertions of dispersed elements in pericentromeric alpha satellites occur preferably at kinkable DNA sites.着丝粒周围α卫星中分散元件的结构重排和插入，优先发生在可弯曲DNA位点。
J Mol Biol. 2001 Jan 5;305(1):33-48. doi: 10.1006/jmbi.2000.4270.
4
Additional dark G-band in the p-arm of chromosome 19 due to a paracentric inversion with a breakpoint in the pericentromeric heterochromatin.
Am J Med Genet. 2001 Oct 1;103(2):160-2. doi: 10.1002/ajmg.1520.
5
Genetic and physical analyses of the centromeric and pericentromeric regions of human chromosome 5: recombination across 5cen.人类5号染色体着丝粒和着丝粒周围区域的遗传与物理分析：5号染色体着丝粒的重组
Genomics. 1999 Mar 15;56(3):274-87. doi: 10.1006/geno.1999.5742.
6
In search of a 9q13 latent centromere in 9qh polymorphic inversions.
Genet Couns. 2001;12(4):359-62.
7
Alphoidless centromere of a familial unstable inverted Y chromosome.
Ann Genet. 1996;39(4):236-9.
8
Molecular characterization of the secondary constriction region (qh) of human chromosome 9 with pericentric inversion.人类9号染色体次缢痕区（qh）伴臂间倒位的分子特征分析
J Cell Sci. 1992 Dec;103 ( Pt 4):919-23. doi: 10.1242/jcs.103.4.919.
9
Inverted duplication involving alpha satellite DNA resulting in a C-negative-band in the qh region of chromosome 16.涉及α卫星DNA的反向重复，导致16号染色体qh区域出现C阴性带。
Am J Med Genet. 1993 May 15;46(3):351-2. doi: 10.1002/ajmg.1320460326.
10
Subfertile couple with inv(2),inv(9) and 16qh+.患有inv(2)、inv(9)和16qh+的不育夫妇。
J Appl Genet. 2004;45(4):477-9.
引用本文的文献
1
Variation in meiotic recombination frequencies among human males.人类男性减数分裂重组频率的变异。
Hum Genet. 2005 Feb;116(3):172-8. doi: 10.1007/s00439-004-1215-6. Epub 2004 Dec 1.
Zotero 插件