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腹腔注射3-硝基丙酸后大鼠纹状体中的细胞凋亡

Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid.

作者信息

Sato S, Gobbel G T, Honkaniemi J, Li Y, Kondo T, Murakami K, Sato M, Copin J C, Chan P H

机构信息

Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143-0651, USA.

出版信息

Brain Res. 1997 Jan 16;745(1-2):343-7. doi: 10.1016/s0006-8993(96)01231-0.

DOI:10.1016/s0006-8993(96)01231-0
PMID:9037431
Abstract

The present study investigated the mechanism of cellular degeneration within the striatum following administration of the mitochondrial toxin, 3-nitropropionic (3-NP) acid. Internucleosomal fragmentation typical of apoptosis was present in the DNA of cells from the striatum of 3-NP-treated rats. DNA fragmentation was also evident in this region by terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. The data suggest that striatal cells die by apoptosis following administration of 3-NP.

摘要

本研究调查了线粒体毒素3-硝基丙酸（3-NP）给药后纹状体内细胞变性的机制。3-NP处理的大鼠纹状体细胞的DNA中存在典型的凋亡核小体间断裂。通过末端脱氧核苷酸转移酶介导的dUTP生物素缺口末端标记，该区域的DNA断裂也很明显。数据表明，给予3-NP后纹状体细胞通过凋亡死亡。

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1
Apoptosis in the striatum of rats following intraperitoneal injection of 3-nitropropionic acid.腹腔注射3-硝基丙酸后大鼠纹状体中的细胞凋亡
Brain Res. 1997 Jan 16;745(1-2):343-7. doi: 10.1016/s0006-8993(96)01231-0.
2
Decreased expression of bcl-2 and bcl-x mRNA coincides with apoptosis following intracerebral administration of 3-nitropropionic acid.脑内注射3-硝基丙酸后，bcl-2和bcl-x mRNA表达降低与细胞凋亡同时出现。
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Major strain differences in response to chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid in rats: implications for neuroprotection studies.大鼠对线粒体毒素3-硝基丙酸慢性全身给药反应的主要品系差异：对神经保护研究的启示
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