Banks B E, Walter S J
J Neurocytol. 1977 Jun;6(3):287-97. doi: 10.1007/BF01175192.
Sectioning of the two major outflows from the superior cervical ganglia in two week mice results in a marked drop in the number of neurons within one week of operation and a smaller drop over the following two weeks. In animals receiving daily injections of nerve growth factor (NGF), the effect of axotomy is modified. One week after axotomy, the number of neurons in the axotomized ganglia is approximately the same in NGF treated animals as in the control, sham operated ganglia. Over the next two weeks, however, the cell death that results from axotomy is no longer prevented by treatment with NGF. The normal, hyperplastic response to NGF appears to occur independently of the cell reaction caused by axotomy.
对两周龄小鼠的颈上神经节的两大主要传出神经进行切断，会导致术后一周内神经元数量显著减少，在接下来的两周内减少幅度较小。在每日注射神经生长因子（NGF）的动物中，轴突切断的影响得到了改变。轴突切断一周后，接受NGF治疗的动物中，轴突切断神经节中的神经元数量与对照假手术神经节中的大致相同。然而，在接下来的两周内，轴突切断导致的细胞死亡不再能被NGF治疗所阻止。对NGF的正常增生反应似乎独立于轴突切断引起的细胞反应而发生。
