二苯并[b,f]氮杂䓬类，第7部分。新型潜在中枢神经系统活性二苯并[b,f]氮杂䓬衍生物的合成。
Dibenz[b,f]azepines, Part 7. Synthesis of new, potentially CNS active dibenz[b,f]azepine derivatives.
作者信息
Haász F, Tóth Z, Galamb V
机构信息
Alkaloida Chemical Company Ltd., Tiszavasvári, Hungary.
出版信息
Arch Pharm (Weinheim). 1996 Dec;329(12):551-3. doi: 10.1002/ardp.19963291207.
PMID:9038423
Abstract
Reactions of 5-carboxamido-5H-dibenz[b,f]azepines (1a-1d) with glyoxylic acid methylester methyl hemiacetal (GMHA) led to 5-(carboxamido-N-alpha-hydroxy-acetic acid methyl ester)-5H- dibenz[b,f]azepines (2a-2d). The reactions with glycols yielded the oligoethylene glycol derivatives (3,4). The new compounds were screened as anticonvulsants and/or antidepressants (AD).
摘要
5-羧酰胺基-5H-二苯并[b,f]氮杂䓬（1a - 1d）与乙醛酸甲酯甲基半缩醛（GMHA）反应生成5-(羧酰胺基-N-α-羟基-乙酸甲酯)-5H-二苯并[b,f]氮杂䓬（2a - 2d）。与二醇反应生成低聚乙二醇衍生物（3,4）。对这些新化合物进行了抗惊厥和/或抗抑郁（AD）筛选。
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