Xue F S, Liao X, Tong S Y, Liu Q H, An G, Luo L K
Chinese Association of Anaesthesiology, People's Republic of China.
Anaesthesia. 1996 Dec;51(12):1102-5. doi: 10.1111/j.1365-2044.1996.tb15041.x.
Thirty-six healthy patients, ASA 1, aged 16-41 years, scheduled for elective plastic surgery were studied to determine if thoracocervical or lumbar epidural blocks affected the lag time of the pulse oximeter response. Patients were allocated to receive thoracocervical epidural block (n = 20) (group 1) (lignocaine 1%) or lumbar epidural block (n = 16) (group 2) (lignocaine 1.5%). Epidural block was performed with a 17-gauge Tuohy needle inserted in the midline between C7-T2 vertebrae in group 1 and between L1-S1 in group 2 and an epidural catheter was introduced. Arterial oxygen saturation (SpO2) was measured continuously using a Datex pulse oximeter. The lag time of the pulse oximeter response was measured while breathing oxygen (100%) after breath-holding. Values were obtained 10 min before and 5, 10, 15, 20, 30, and 40 min after epidural injection of a test dose. There was a progressive decrease in the lag time of the pulse oximeter response so that by 30 min after epidural injection the mean (SD) value had decreased from 29 (6.1) to 14 (3.4) in Group 1 and 41 (12.8) to 23 (7.9) s in group 2 (p < 0.01).
36名年龄在16 - 41岁、ASA 1级、计划接受择期整形手术的健康患者参与了研究，以确定胸颈段或腰段硬膜外阻滞是否会影响脉搏血氧饱和度仪反应的延迟时间。患者被分配接受胸颈段硬膜外阻滞（n = 20）（第1组）（1%利多卡因）或腰段硬膜外阻滞（n = 16）（第2组）（1.5%利多卡因）。第1组在C7 - T2椎体之间的中线处以及第2组在L1 - S1之间，用17号Tuohy针进行硬膜外阻滞，并置入硬膜外导管。使用Datex脉搏血氧饱和度仪持续测量动脉血氧饱和度（SpO2）。在屏气后呼吸纯氧（100%）时测量脉搏血氧饱和度仪反应的延迟时间。在硬膜外注射试验剂量前10分钟以及注射后5、10、15、20、30和40分钟获取数值。脉搏血氧饱和度仪反应的延迟时间逐渐缩短，以至于在硬膜外注射后30分钟时，第1组的平均（标准差）值从29（6.1）秒降至14（3.4）秒，第2组从41（12.8）秒降至23（7.9）秒（p < 0.01）。
