Seow-Choen F, Vijayan V, Keng V
Department of Colorectal Surgery, Singapore General Hospital, Singapore.
Br J Surg. 1996 Dec;83(12):1763-6. doi: 10.1002/bjs.1800831232.
Eighteen patients with familial adenomatous polyposis (FAP) who had previously undergone colectomy but had upper gastrointestinal polyps were studied in a double-blind randomized crossover trial comparing sulindac with calcium and calciferol. Sulindac produced a reduction in the crypt proliferation index in the gastric epithelium of patients but did not significantly affect duodenal mucosa. Calcium with calciferol did not have any effects on crypt proliferation index in patients with FAP.
18例家族性腺瘤性息肉病（FAP）患者曾接受过结肠切除术，但存在上消化道息肉，在一项双盲随机交叉试验中对舒林酸与钙及骨化醇进行了比较研究。舒林酸使患者胃上皮隐窝增殖指数降低，但对十二指肠黏膜无显著影响。钙与骨化醇对FAP患者的隐窝增殖指数没有任何影响。
