Kösel S, Egensperger R, von Eitzen U, Mehraein P, Graeber M B
Molecular Neuropathology Laboratory, Ludwig-Maximilians University, Munich, Germany.
Acta Neuropathol. 1997 Feb;93(2):105-8. doi: 10.1007/s004010050590.
Apoptosis has been postulated as a mechanism of nerve cell death in Parkinson's disease. In the present study, the substantia nigra of 22 neuropathologically confirmed Parkinson cases and 8 control brains was studied using the in situ end-labeling (TUNEL) method. About 50% of parkinsonian brains showed a small number of TUNEL-positive glial cells in the substantia nigra, whereas no neurons showed convincing TUNEL positivity or any morphological signs of apoptosis. No correlation was observed between the number of TUNEL-positive glial cells and microglial activation. Our results fail to demonstrate apoptosis as a mechanism of cell death in Parkinson's disease.
细胞凋亡被认为是帕金森病中神经细胞死亡的一种机制。在本研究中，使用原位末端标记（TUNEL）方法对22例经神经病理学确诊的帕金森病病例和8个对照脑的黑质进行了研究。约50%的帕金森病脑黑质中可见少量TUNEL阳性胶质细胞，而未见神经元有令人信服的TUNEL阳性或任何凋亡形态学迹象。未观察到TUNEL阳性胶质细胞数量与小胶质细胞活化之间存在相关性。我们的结果未能证明细胞凋亡是帕金森病中细胞死亡的机制。
