Grandin C B, Van Beers B E, Pauwels S, Demeure R, Jamart J, Pringot J
Department of Radiology, St. Luc University Hospital, Catholic University of Louvain, Brussels, Belgium.
J Magn Reson Imaging. 1997 Jan-Feb;7(1):125-9. doi: 10.1002/jmri.1880070117.
The tumor-to-liver uptake of two reticuloendothelial agents, namely ferumoxides and technetium-99m (Tc-99m) sulfur colloid, was compared in focal nodular hyperplasia (FNH). Twelve patients with FNH who had undergone ferumoxides-enhanced MR imaging and planar Tc-99m sulfur colloid scintigraphy within 1 year were included from the study. Fourteen patients with FNH with a diameter larger than 3 cm were selected for the comparison. The tumor-to-liver ferumoxides uptake was calculated and the Tc-99m sulfur colloid uptake was assessed visually. Fermuoxides uptake was observed in all but one patient with FNH (mean tumor-to-liver ratio = .36). The six tumors showing normal (n = 5) or increased (n = 1) radiocolloid uptake when compared to the liver accumulated more ferumoxides than the eight tumors showing decreased radiocolloid uptake (P < .01). However, in some tumors, no direct relation was observed between ferumoxides and Tc-99m sulfur colloid uptake. Our observations suggest that ferumoxides uptake might not exactly mimic Tc-99m sulfur colloid uptake in FNH.
在局灶性结节性增生（FNH）中，比较了两种网状内皮细胞剂，即超顺磁性氧化铁和锝-99m（Tc-99m）硫胶体的肿瘤与肝脏摄取情况。该研究纳入了12例在1年内接受过超顺磁性氧化铁增强磁共振成像和平面Tc-99m硫胶体闪烁扫描的FNH患者。选择了14例直径大于3 cm的FNH患者进行比较。计算肿瘤与肝脏的超顺磁性氧化铁摄取率，并通过视觉评估Tc-99m硫胶体摄取情况。除1例FNH患者外，其他所有患者均观察到超顺磁性氧化铁摄取（平均肿瘤与肝脏比值 = 0.36）。与肝脏相比，6个显示放射性胶体摄取正常（n = 5）或增加（n = 1）的肿瘤比8个显示放射性胶体摄取减少的肿瘤积累了更多的超顺磁性氧化铁（P < 0.01）。然而，在一些肿瘤中，未观察到超顺磁性氧化铁与Tc-99m硫胶体摄取之间存在直接关系。我们的观察结果表明，在FNH中，超顺磁性氧化铁摄取可能无法准确模拟Tc-99m硫胶体摄取。
