Fujisawa H, Nakayama K, Nomura T, Kawachi Y, Otsuka F
Department of Dermatology, Institute of Clinical Medicine, University of Tsukuba, Ibaraki, Japan.
J Dermatol Sci. 1997 Feb;14(2):109-14. doi: 10.1016/s0923-1811(96)00558-0.
We show that in two cell lines of human squamous cell carcinoma (SCC) which slightly express intercellular adhesion molecule-1 (ICAM-1), the expression is enhanced not only by interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) but also by interleukin-1 (IL-1) and lipopolysaccharide (LPS). This expression is totally dependent on the increase of ICAM-1 mRNA. This evidence contrasts with previously reported findings indicating that, in human cultured keratinocytes, ICAM-1 expression is induced by IFN-gamma and TNF-alpha, and not by either IL-1 or LPS. This result suggests that various cytokines or agents easily enhance ICAM-1 expression in SCC cell lines, and may explain the clinical finding that ICAM-1 expression increases according to the progression of malignant tumors.
我们发现，在两种轻度表达细胞间黏附分子-1（ICAM-1）的人鳞状细胞癌（SCC）细胞系中，不仅干扰素-γ（IFN-γ）和肿瘤坏死因子-α（TNF-α）可增强其表达，白细胞介素-1（IL-1）和脂多糖（LPS）也可增强其表达。这种表达完全依赖于ICAM-1 mRNA的增加。这一证据与先前报道的结果形成对比，先前报道表明，在人培养的角质形成细胞中，ICAM-1表达由IFN-γ和TNF-α诱导，而非由IL-1或LPS诱导。这一结果表明，多种细胞因子或物质可轻易增强SCC细胞系中ICAM-1的表达，这可能解释了ICAM-1表达随恶性肿瘤进展而增加的临床发现。
