Rodriguez C, Bugay D E
Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, NJ 08903, USA.
J Pharm Sci. 1997 Feb;86(2):263-6. doi: 10.1021/js960286z.
The combined physical analytical technique of thermogravimetric and infrared analysis (TG/IR) is described for the investigation of pharmaceutical solids. TG/IR provides an unequivocal identification of the volatile content of a pharmaceutical solid. In the case of pharmaceutical solvates, TG/IR provides identification of the evolved gas from the crystalline solid. Variable temperature X-ray diffraction and differential scanning calorimetry techniques provide the required information to ascertain whether the evolved gas was due to a solvent incorporated into the crystal lattice or physically adsorbed onto the solid. This work illustrates three examples of TG/IR as utilized in a multidisciplinary approach to the physical characterization of pharmaceutical solids.
描述了用于研究药物固体的热重分析和红外分析相结合的物理分析技术（TG/IR）。TG/IR能明确鉴定药物固体的挥发性成分。对于药物溶剂化物，TG/IR能鉴定出从结晶固体中逸出的气体。可变温度X射线衍射和差示扫描量热法技术提供了所需信息，以确定逸出的气体是由于晶格中掺入的溶剂还是物理吸附在固体上。这项工作展示了TG/IR在多学科方法中用于药物固体物理表征的三个例子。
