Boeles S, Williams C, Campling G M, Goodall E M, Cowen P J
University Department of Psychiatry, Littlemore Hospital, Oxford, UK.
Psychopharmacology (Berl). 1997 Jan;129(2):179-82. doi: 10.1007/s002130050178.
We studied the effect of the 5-HT1B/ID receptor agonist sumatriptan (6 mg s.c.) on plasma growth hormone and prolactin and food intake in 15 healthy female subjects using a double-blind, placebo-controlled, cross-over design. Sumatriptan significantly elevated plasma growth hormone but did not alter plasma prolactin. Sumatriptan also significantly lowered total food intake in a buffet meal, particularly decreasing the intake of fat. Our results indicate that 5-HT1B/ID receptors may be involved in the regulation of food intake in humans. In addition, while activation of 5-HT1B/ID receptors stimulates growth hormone release in both men and women, sumatriptan lowers plasma prolactin only in men, suggesting sex differences in the 5-HT regulation of prolactin release.
我们采用双盲、安慰剂对照、交叉设计，研究了5-羟色胺1B/ID受体激动剂舒马曲坦（皮下注射6毫克）对15名健康女性受试者血浆生长激素、催乳素及食物摄入量的影响。舒马曲坦显著提高了血浆生长激素水平，但未改变血浆催乳素水平。舒马曲坦还显著降低了自助餐中的总食物摄入量，尤其是减少了脂肪的摄入量。我们的结果表明，5-羟色胺1B/ID受体可能参与人体食物摄入量的调节。此外，虽然5-羟色胺1B/ID受体的激活在男性和女性中均刺激生长激素释放，但舒马曲坦仅在男性中降低血浆催乳素水平，提示5-羟色胺对催乳素释放的调节存在性别差异。
