Hogan S C, Stratford K J, Moore D R
University Laboratory of Physiology, Oxford.
BMJ. 1997 Feb 1;314(7077):350-3. doi: 10.1136/bmj.314.7077.350.
To monitor the natural course of otitis media with effusion.
Prospective, longitudinal assessment of the state of the middle ear by otoscopy and tympanometry at monthly intervals from birth to 3 years.
Domiciliary visits to family homes.
95 full term infants born between August 1991 and November 1993.
Observed and simulated data (Monte Carlo) for the duration of single episodes of otitis media with effusion.
17 of the children had unilateral or bilateral otitis media with effusion for more than half of their first three years of life. Thirty three of the 95 children had tympanograms suggestive of otitis media with effusion at more than a third of observations; the remaining 62 had such tympanograms at less than a third of observations. The data of each group were described by a first order Markov model, yielding a mean duration of unilateral effusion episodes of 5-6 weeks in both groups; the mean duration of bilateral effusion was 6 and 10 weeks in the low and high incidence groups, respectively. However, the main difference between the groups was the time spent between episodes of effusion: effusion free periods were, on average, three times longer in the children who experienced less otitis media with effusion.
Children who are susceptible to otitis media with effusion tend to have more separate episodes of effusion rather than an increased overall duration of episodes. Such children are primarily distinguished by the likelihood with which they acquire the disease than by their ability to recover from it.
监测分泌性中耳炎的自然病程。
从出生至3岁,每月通过耳镜检查和鼓室图对中耳状态进行前瞻性纵向评估。
上门家访。
1991年8月至1993年11月出生的95名足月儿。
分泌性中耳炎单次发作持续时间的观察数据和模拟数据(蒙特卡洛法)。
17名儿童在其生命的前三年中,有超过一半时间患有单侧或双侧分泌性中耳炎。95名儿童中有33名在超过三分之一的观察中鼓室图提示分泌性中耳炎;其余62名儿童在不到三分之一的观察中出现此类鼓室图。每组数据均用一阶马尔可夫模型描述,两组单侧积液发作的平均持续时间均为5 - 6周;低发组和高发组双侧积液的平均持续时间分别为6周和10周。然而,两组之间的主要差异在于积液发作之间的间隔时间:积液较少的儿童无积液期平均长三倍。
易患分泌性中耳炎的儿童往往有更多次独立的积液发作,而非发作的总时长增加。这类儿童的主要区别在于患病的可能性,而非从疾病中恢复的能力。