Kadipasaoglu K A, Pehlivanoglu S, Conger J L, Sasaki E, de Villalobos D H, Cloy M, Piluiko V, Clubb F J, Cooley D A, Frazier O H
Cardiovascular Research Laboratory, Texas Heart Institute, Houston 77030, USA.
Lasers Surg Med. 1997;20(1):6-14. doi: 10.1002/(sici)1096-9101(1997)20:1<6::aid-lsm2>3.0.co;2-u.
This study examined the effect of transmyocardial laser revascularization (TMLR) on infarct size and global and regional left ventricular (LV) function.
STUDY DESIGN/MATERIALS AND METHODS: Acute ischemia was induced in 24 dogs by ligating the left anterior descending artery. TMLR was done through a left thoracotomy in 12 dogs. The 12 control dogs had ligation only. Global and regional LV function were measured before ligation, then at 6 hours or 3 months after ligation. We calculated the volumetric ratio of damaged myocardium to myocardium at risk (Vd/Vr).
At 6 hours, global compensation despite regional dyskinesia was universal; Vd/Vr was the same in control and TMLR dogs. At 3 months, global function during stress was significantly higher in TMLR dogs than in control dogs (P < .05); regional contractions were synergic only in TMLR dogs; mean Vd/Vr was significantly lower in TMLR dogs.
TMLR limits infarct expansion and improves long-term global and regional function after acute ischemia.
本研究探讨经心肌激光血运重建术（TMLR）对梗死面积以及左心室（LV）整体和局部功能的影响。
研究设计/材料与方法：通过结扎左前降支动脉，在24只犬中诱导急性缺血。12只犬通过左胸切开术进行TMLR。12只对照犬仅进行结扎。在结扎前、结扎后6小时或3个月测量LV整体和局部功能。我们计算了受损心肌与危险心肌的容积比（Vd/Vr）。
6小时时，尽管存在局部运动障碍，但整体代偿普遍存在；对照犬和TMLR犬的Vd/Vr相同。3个月时，TMLR犬在应激期间的整体功能显著高于对照犬（P <.05）；仅在TMLR犬中局部收缩是协同的；TMLR犬的平均Vd/Vr显著更低。
TMLR可限制急性缺血后梗死扩展并改善长期整体和局部功能。
