Romano A, Pietrantonio F
Istituto di Medicina Interna e Geriatria. Università Cattolica del Sacro Cuore, Rome, Italy.
J Intern Med. 1997 Jan;241(1):81-3. doi: 10.1046/j.1365-2796.1997.64887000.x.
Immune-mediated reactions to nonsteroidal anti-inflammatory drugs (NSAIDs) are unusual, and true allergy to the drug flurbiprofen has never been documented. We observed a patient who developed a maculopapular rash 48 h after beginning oral therapy with this drug, and 2 days later, angioedema and hypotension. Patch tests with flurbiprofen were positive 48 and 72 h after application. The clinical and allergologic features of this case strongly suggest type IV hypersensitivity. Patch testing with NSAIDs is useful for confirming clinical diagnoses of delayed hypersensitivity to these drugs.
对非甾体抗炎药（NSAIDs）的免疫介导反应并不常见，且从未有过对氟比洛芬药物真正过敏的记录。我们观察到一名患者在开始口服该药物治疗48小时后出现斑丘疹，2天后出现血管性水肿和低血压。应用氟比洛芬进行斑贴试验，在48小时和72小时后呈阳性。该病例的临床和过敏学特征强烈提示为IV型超敏反应。使用NSAIDs进行斑贴试验有助于确诊对这些药物的迟发型超敏反应的临床诊断。
