Sandin J, Georgieva J, Schött P A, Ogren S O, Terenius L
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Eur J Neurosci. 1997 Jan;9(1):194-7. doi: 10.1111/j.1460-9568.1997.tb01367.x.
The newly discovered peptide nociceptin/orphanin FQ has been found to increase reactivity to pain and to influence locomotor activity after intracerebroventricular administration. This study investigated the possible role of hippocampal nociceptin/orphanin FQ in spatial learning and in spontaneous locomotion. Male rats were trained in the Morris water task after microinjection of 10 nmol nociceptin/orphanin FQ or artificial cerebrospinal fluid (as control) into the CA3 region of the dorsal hippocampus. Nociceptin/orphanin FQ was found to severely impair spatial learning without interfering with swimming performance. Intrahippocampal injection of nociceptin/ orphanin FQ markedly decreased exploratory locomotor activity including vertical movements (rearing). The data suggest that nociceptin/orphanin FQ is a potent modulator of synaptic plasticity within the hippocampus.
新发现的肽痛敏肽/孤啡肽FQ已被发现在脑室内给药后会增加对疼痛的反应性并影响运动活性。本研究调查了海马体中痛敏肽/孤啡肽FQ在空间学习和自发运动中可能发挥的作用。在将10纳摩尔痛敏肽/孤啡肽FQ或人工脑脊液（作为对照）微量注射到雄性大鼠背侧海马体的CA3区后，对其进行莫里斯水迷宫任务训练。结果发现，痛敏肽/孤啡肽FQ严重损害空间学习能力，但不影响游泳表现。海马体内注射痛敏肽/孤啡肽FQ显著降低了探索性运动活性，包括垂直运动（竖毛）。数据表明，痛敏肽/孤啡肽FQ是海马体内突触可塑性的有效调节剂。
