Antithrombotic effect in vivo of thrombotic substances adsorbed on a platinum surface.

Thrombus deposits on foreign surfaces in contact with blood. Substances adsorbed on the surface can influence thrombus formation. Platelet activator substances and coagulation components thrombin and fibrinogen, were adsorbed onto respective series of platinum wire. A treated wire and a control untreated wire inserted for one hour into the vena cava in groups of rats and the deposited thrombus was weighed. A control group of rats bore two untreated wires which attracted similar thrombus. Arachidonic acid and adenosine diphosphate negligibly affected thrombus. Collagen, fibrinogen, thrombin and egg albumin significantly reduced thrombus deposits by up to 85%.