Patel P R, Cook S E
Cephalon, Inc., Westchester, PA, USA.
Am J Health Syst Pharm. 1997 Feb 15;54(4):412-21. doi: 10.1093/ajhp/54.4.412.
The stability of meropenem in various i.v. fluids stored in various containers for i.v. use was studied. Solutions of meropenem were prepared in a variety of i.v. diluents in polyvinyl chloride (PVC) bags, glass vials, and commercial easy-to-prepare infusion systems. Solutions for storage in PVC bags were prepared with meropenem concentrations of 1 and 20 mg/mL; in glass vials, 2.5 and 50 mg/mL; and in commercial easy-to-prepare infusion systems, 2.5 and 20 mg/mL (Baxter Minibag Plus system) and 1, 5, and 20 mg/mL (ADD-Vantage system, Abbott). The solutions were stored for up to 48 hours at 4-5 or 21-26 degrees C. Meropenem concentrations were determined by high-performance liquid chromatography. The stability of meropenem was influenced by the drug concentration; the drug was stable for a longer time in the 1-mg/mL solution than in the 20- and 50-mg/mL solutions. Stability was also influenced by storage temperature; the drug was stable for a longer time in solutions stored at 4-5 degrees C than in solutions stored at 21-26 degrees C. Meropenem was stable for the longest time in sterile water for injection and in 0.9% sodium chloride injection. The stability of meropenem in solutions in PVC bags, glass vials, Baxter Minibag Plus containers, and ADD-Vantage bags was influenced by the i.v. fluid used to reconstitute the drug, the concentration of the final solution, and the storage temperature.
研究了美罗培南在各种用于静脉注射的容器中储存于不同静脉输液中的稳定性。美罗培南溶液在聚氯乙烯（PVC）袋、玻璃瓶和市售易制备输液系统中的多种静脉稀释剂中配制。储存在PVC袋中的溶液，美罗培南浓度为1和20mg/mL；在玻璃瓶中，为2.5和50mg/mL；在市售易制备输液系统中，（百特MiniBag Plus系统）为2.5和20mg/mL，（雅培ADD-Vantage系统）为1、5和20mg/mL。溶液在4 - 5℃或21 - 26℃下储存长达48小时。通过高效液相色谱法测定美罗培南浓度。美罗培南的稳定性受药物浓度影响；在1mg/mL溶液中比在20mg/mL和50mg/mL溶液中稳定时间更长。稳定性还受储存温度影响；在4 - 5℃储存的溶液中比在21 - 26℃储存的溶液中稳定时间更长。美罗培南在注射用无菌水和0.9%氯化钠注射液中稳定时间最长。美罗培南在PVC袋、玻璃瓶、百特MiniBag Plus容器和ADD-Vantage袋中的溶液稳定性受用于复溶药物的静脉输液、最终溶液浓度和储存温度影响。
