Effect of several antidepressant drugs on isolated rat vas deferens in vitro.

Imipramine-N-oxide, quinupramine, clomipramine, doxepin, maprotiline, amineptine, amoxapine, mianserin, minaprine, nomifensine, viloxacine, trazodone and lofepramine effects were studied on rat vas deferens responses to noradrenaline. Tissues were prepared in Krebs-Henseleit solution with and without adding cocaine. 17 beta-estradiol and propranolol for blocking neuronal and extraneuronal noradrenaline reuptake. In normal Krebs-Henseleit solution imipramine-N-oxide, nomifensine, viloxacine and lofepramine increased noradrenaline responses, while clomipramine, trazodone and doxepin behaved as competitive antagonists. When adding cocaine, 17 beta-estradiol and propranolol to the solution there was antagonism but no increase in responses.