Sáenz-Campos D, Bayés M C, Masana E, Martín S, Barbanoj M, Jané F
Department of Pharmacology and Clinical Toxicology, Faculty of Medicine, University of Costa Rica.
Methods Find Exp Clin Pharmacol. 1996 Oct;18(8):533-8.
The aim of the present study was to determine whether or not the pharmacokinetic and hemodynamic response to a 20 mg single oral dose of lisinopril was sex-dependent. Thirty-two young healthy volunteers (16 males and 16 females) were included in the trial. Blood samples to assess lisinopril plasma concentrations, determined indirectly by inhibition of the angiotensin converting enzyme (ACE) and hemodynamic variables, were obtained before and at different times following drug intake. No significant differences in pharmacokinetic parameters were observed between males and females. An hypotensive response was obtained between 2 and 10 h for systolic blood pressure and between 2 and 24 h for diastolic blood pressure. Again, no significant sex-related differences were noted. Lisinopril was well tolerated.
本研究的目的是确定单次口服20毫克赖诺普利后的药代动力学和血流动力学反应是否存在性别差异。32名年轻健康志愿者（16名男性和16名女性）参与了该试验。在服药前及服药后的不同时间采集血样，以评估赖诺普利的血浆浓度（通过抑制血管紧张素转换酶（ACE）间接测定）和血流动力学变量。男性和女性之间未观察到药代动力学参数的显著差异。收缩压在服药后2至10小时出现降压反应，舒张压在服药后2至24小时出现降压反应。同样，未发现显著的性别相关差异。赖诺普利耐受性良好。
