黄色粘球菌细胞外纤维进行的ADP核糖基化作用。

ADP-ribosylation by the extracellular fibrils of Myxococcus xanthus.

作者信息

Hildebrandt K, Eastman D, Dworkin M

机构信息

Department of Microbiology, University of Minnesota, Minneapolis 55455-0312, USA.

出版信息

Mol Microbiol. 1997 Jan;23(2):231-5. doi: 10.1046/j.1365-2958.1997.2111575.x.

DOI:10.1046/j.1365-2958.1997.2111575.x

PMID:9044257

Abstract

The isolated, extracellular fibrils of the myxobacterium, Myxococcus xanthus, are capable of carrying out ADP-ribosylation. The substrate for the ADP-ribosylation is reactive with monoclonal antibody 2105, which has been shown to be directed specifically against the integral fibril proteins. The extracellular fibrils thus contain both the ADP-ribosyl transferase and the substrate for the ribosylation. This process may play a role in the contact-mediated cell-cell interactions that are an important part of the social behaviour of M. xanthus.

摘要

粘细菌黄色粘球菌的分离细胞外纤维能够进行ADP核糖基化。ADP核糖基化的底物与单克隆抗体2105发生反应，该抗体已被证明能特异性针对完整的纤维蛋白。因此，细胞外纤维既含有ADP核糖基转移酶，也含有核糖基化的底物。这一过程可能在接触介导的细胞间相互作用中发挥作用，而这种相互作用是黄色粘球菌社会行为的重要组成部分。