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[清醒猫肾实质性高血压发展过程中压力感受器反射敏感性的变化]

[Changes in the sensitivity of the baroreceptor reflex during the development of renal parenchymatous hypertension in waking cats].

作者信息

Rozin B D, Orlova Ts R, Zhigalina S G

出版信息

Fiziol Zh (1994). 1996;42(5-6):26-32.

PMID:9044807
Abstract

Hemodynamic parameters were investigated in experiments with chronically instrumented hypertensive cats. It was shown, that mean arterial pressure level raised by 35%, heart rate decreased by 20% and peripheral resistance raised by 56% in awake hypertensive cats. The study demonstrates that the mean blood pressure raised on the 30th day after hypertension induction, however, baroreflex sensitivity lowered only on the 40th day. The values of the system hemodynamics indices permit considering that the model of hypertension in awake cats has been worked out for the first time.

摘要

在对慢性植入仪器的高血压猫进行的实验中研究了血流动力学参数。结果表明,清醒的高血压猫的平均动脉压水平升高了35%,心率降低了20%,外周阻力升高了56%。该研究表明,高血压诱导后第30天平均血压升高,但压力反射敏感性仅在第40天降低。系统血流动力学指标的值表明首次建立了清醒猫的高血压模型。

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