Lee G H, Bugni J M, Obata M, Nishimori H, Ogawa K, Drinkwater N R
Department of Pathology, Asahikawa Medical College, Nishikagura, Japan.
Cancer Res. 1997 Feb 15;57(4):590-3.
The LT/Sv mouse strain is characterized by its abnormally high incidence of spontaneous ovarian teratomas. These tumors have been shown to originate from parthenogenetic oocytes, which are spontaneously induced to divide. Both spontaneous parthenogenesis and ovarian teratomas are extremely rare for other mouse strains, including C57BL/6J. To identify the genes responsible for this unique phenotype of female LT/Sv mice, we performed linkage analysis of female (C57BL/6J x LT/Sv)F2 mice. A locus on chromosome 6 designated Ots1 (ovarian teratoma susceptibility) was identified as the single major locus that increases the frequency of teratomas in a semidominant manner.
LT/Sv小鼠品系的特征是自发性卵巢畸胎瘤的发病率异常高。这些肿瘤已被证明起源于孤雌生殖的卵母细胞，这些卵母细胞会自发地被诱导分裂。对于包括C57BL/6J在内的其他小鼠品系来说，自发孤雌生殖和卵巢畸胎瘤都极为罕见。为了鉴定导致雌性LT/Sv小鼠这种独特表型的基因，我们对雌性（C57BL/6J×LT/Sv）F2小鼠进行了连锁分析。位于6号染色体上的一个名为Ots1（卵巢畸胎瘤易感性）的位点被确定为以半显性方式增加畸胎瘤发生频率的单一主要位点。
