Domenegati E, Ceriana P, Chiaudani M G, Pagani F
I Servizio di Anestesia e Rianimazione, IRCCS Policlinico S. Matteo, Pavia.
Minerva Anestesiol. 1996 Jun;62(6):219-27.
To review experience with anaesthetic management in patients undergoing a left ventricular assist system (LVAS) Novacor implant as a bridge to cardiac transplantation.
Retrospective clinical study.
Cardiothoracic operating room in a university hospital.
Nine, aged 37-62 years, suffering from 8 dilated and 1 postischemic cardiomyopathy at end stage heart failure. INTERVENTIONS OR METHODS: Under general anaesthesia and cardio-pulmonary bypass the LVAS pump is placed in the abdomen and connected to the left ventricle through an inflow cannula and to the aorta through an outflow cannula. The pump has an output of 5-7 l/min and works in synchronous counterpulsation with the left ventricle.
The mean Novacor support has been 75.56 days (DS +/- 85.95). Five out of 9 patients have been transplanted, while 3 are still waiting at home. Pretransplant CI was on average 1.66 l/min/m2 (DS +/- 0.27) and REF 11.44% (DS +/- 5.29); after the Novacor implant CI was 3.44 (DS +/- 0.49) and REF 22.22% (DS +/- 4.49).
A LVAS can bridge patients to heart transplantation while improving or preserving their health conditions. Some factors are to be taken into account for the anaesthesiological management of the implant/explant of a LVAS: the patients' poor clinical conditions; the knowledge of the components and functioning of the LVAS that conditions the choice of the anaesthesiological drugs and volemia; the unassisted right ventricle function that has to be pharmacologically supported; the bleeding problem because of the adherences during the explant surgery.
回顾左心室辅助系统(LVAS)诺瓦科尔植入术作为心脏移植桥梁的患者麻醉管理经验。
回顾性临床研究。
大学医院心胸手术室。
9例,年龄37 - 62岁,患有8例扩张型心肌病和1例缺血后心肌病,处于终末期心力衰竭。
在全身麻醉和体外循环下,将LVAS泵置于腹部,通过流入插管连接到左心室,通过流出插管连接到主动脉。该泵输出量为5 - 7升/分钟,与左心室同步进行反搏。
诺瓦科尔平均支持时间为75.56天(标准差±85.95)。9例患者中有5例已接受移植,3例仍在家中等待。移植前心脏指数平均为1.66升/分钟/平方米(标准差±0.27),射血分数为11.44%(标准差±5.29);诺瓦科尔植入后心脏指数为3.44(标准差±0.49),射血分数为22.22%(标准差±4.49)。
LVAS可作为患者心脏移植的桥梁,同时改善或维持其健康状况。LVAS植入/取出的麻醉管理需考虑一些因素:患者临床状况差;了解LVAS的组件和功能,这决定了麻醉药物和血容量的选择;必须通过药物支持未辅助的右心室功能;取出手术中因粘连导致的出血问题。