Caldarella A, Comin C E, Palomba A, Tamburini A, Tintori V
Istituto di Anatomia e Istologia Patologica, Università di Firenze.
Pathologica. 1996 Jun;88(3):175-80.
Two cases of adrenal cortical carcinoma in the pediatric age group are reported: the first case regards a fourteen month old female patient which presented with virilization and Cushing's syndrome: the second case regards a twelve year old boy with severe hypertension. Histopathologic distinction between benign and malignant adrenal cortical neoplasms is difficult: the usual cytologic criteria of benignity and malignancy in relation to prognosis are not very helpful while tumor size and tumor invasion appear to be the more important prognostic factors. Therefore early diagnosis, which is easier in the pediatric age because of the more frequent presentation of these neoplasms with hormonal effects, is essential.
第一例是一名14个月大的女性患者，表现为男性化和库欣综合征；第二例是一名12岁男孩，患有严重高血压。肾上腺皮质良性和恶性肿瘤的组织病理学区分困难：通常与预后相关的良性和恶性细胞学标准帮助不大，而肿瘤大小和肿瘤侵犯似乎是更重要的预后因素。因此，早期诊断至关重要，由于这些肿瘤在小儿时期因激素作用表现更为常见，所以早期诊断在小儿年龄组更容易。
