Nyholm H C, Christensen I J, Nielsen A L
Gynaekologisk-obstetrisk afdeling, H:S Hvidovre Hospital.
Ugeskr Laeger. 1997 Jan 27;159(5):601-4.
Oestrogen receptor (ER) and progesterone receptor (PR) contents were determined by biochemical (dextran charcoal-coated (DCC) assay) and immunohistochemical (ICA) methods in biopsies from 145 primary endometrial adenocarcinomas. Correlations between receptor contents and cancer specific survival were examined in a multivariate analysis including histopathological characteristics. Median patient follow-up time was 67 months with 18 cancer deaths. "High" PR levels correlated significantly (p = 0.004) with survival, independently of stage risk group (stages Ia-Ib vs Ic-IV). Patient age and histological grade were prognostic factors in a univariate setting but these parameters were eliminated in the multivariate model. The association between PR contents and cancer survival suggests that determination of PR can be of importance in the evaluation of endometrial cancer.
采用生化方法（葡聚糖包被活性炭（DCC）分析法）和免疫组织化学方法（ICA）测定了145例原发性子宫内膜腺癌活检组织中的雌激素受体（ER）和孕激素受体（PR）含量。在一项包括组织病理学特征的多变量分析中，研究了受体含量与癌症特异性生存率之间的相关性。患者的中位随访时间为67个月，有18例癌症死亡。“高”PR水平与生存率显著相关（p = 0.004），与分期风险组无关（Ia-Ib期与Ic-IV期）。在单变量分析中，患者年龄和组织学分级是预后因素，但在多变量模型中这些参数被排除。PR含量与癌症生存率之间的关联表明，PR的测定在子宫内膜癌评估中可能具有重要意义。
