Kretzschmar C
Institut für Bakteriologie and Mykologie der Veterinärmedizinischen Fakultät, Universität Leipzig, Deutschland.
Zentralbl Veterinarmed B. 1996 Nov;43(9):525-38.
Tumor-necrosis factor alpha (TNF) has been shown to have a pivotal role in mediating biological effects of endotoxins. Therefore, TNF measurement in the circulation is thought to be a useful diagnostic and prognostic instrument in patients exposed to endotoxin. However, the character of the TNF response depends on the mode of endotoxin exposure and is influenced by a variety of factors. Furthermore, to interpret the TNF state, the regulative effects of the two soluble TNF receptors have to be considered. Finally, the current techniques of TNF determination have to be improved and standardized to obtain reliable and comparable results and to establish TNF measurement as a valuable laboratory parameter.
肿瘤坏死因子α（TNF）已被证明在介导内毒素的生物学效应中起关键作用。因此，循环中TNF的测定被认为是暴露于内毒素患者有用的诊断和预后指标。然而，TNF反应的特征取决于内毒素暴露的方式，并受多种因素影响。此外，为了解释TNF状态，必须考虑两种可溶性TNF受体的调节作用。最后，必须改进和标准化目前的TNF测定技术，以获得可靠且可比的结果，并将TNF测定确立为有价值的实验室参数。
