I 型代谢型谷氨酸受体 mGluR1α 和 mGluR5a：在大鼠视网膜的两个突触层中的定位。
Group I metabotropic glutamate receptors mGluR1alpha and mGluR5a: localization in both synaptic layers of the rat retina.
作者信息
Koulen P, Kuhn R, Wässle H, Brandstätter J H
机构信息
Max-Planck-Institut für Hirnforschung, Abteilung für Neuroanatomie, D-60528 Frankfurt am Main, Germany.
出版信息
J Neurosci. 1997 Mar 15;17(6):2200-11. doi: 10.1523/JNEUROSCI.17-06-02200.1997.
Abstract
We examined the distribution of the group I metabotropic glutamate receptors, mGluR1alpha and mGluR5a, in the adult rat retina and during postnatal development using receptor-specific antisera. In contrast to the restricted localization of group II and group III mGluRs to either the outer plexiform layer (OPL) or the inner plexiform layer (IPL), group I mGluRs are present in both synaptic layers in the rat retina. Double-labeling experiments and electron microscopy showed that in the OPL the two receptors are localized on the dendritic tips of bipolar cells postsynaptic to photoreceptor terminals. In the IPL the two mGluRs are localized on amacrine cell processes postsynaptic to bipolar cell terminals. These results suggest that group I mGluRs are involved in synaptic processing in both plexiform layers and in both the scotopic and photopic pathways in the rat retina. We propose that mGluR1alpha and mGluR5a play an important modulatory role in the responses of retinal neurons to inhibitory and excitatory neurotransmitters.
摘要
我们使用受体特异性抗血清，研究了I型代谢型谷氨酸受体mGluR1α和mGluR5a在成年大鼠视网膜以及出生后发育过程中的分布情况。与II型和III型代谢型谷氨酸受体局限于外网状层（OPL）或内网状层（IPL）不同，I型代谢型谷氨酸受体在大鼠视网膜的两个突触层中均有表达。双重标记实验和电子显微镜显示，在OPL中，这两种受体定位于光感受器终末突触后双极细胞的树突尖端。在IPL中，这两种代谢型谷氨酸受体定位于双极细胞终末突触后无长突细胞的突起上。这些结果表明，I型代谢型谷氨酸受体参与了大鼠视网膜两个网状层以及暗视觉和明视觉通路中的突触处理过程。我们提出，mGluR1α和mGluR5a在视网膜神经元对抑制性和兴奋性神经递质的反应中发挥重要的调节作用。
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