Kaino M, Kondoh S, Okita S, Ryozawa S, Hatano S, Shiraishi K, Kaino S, Akiyama T, Okita K, Kawano T
First Department of Internal Medicine, Yamaguchi University School of Medicine, Ube.
Jpn J Cancer Res. 1996 Dec;87(12):1195-8. doi: 10.1111/j.1349-7006.1996.tb03132.x.
There has been no report on p53 gene mutation in benign human pancreatic intraductal tumors. We examined pancreatic juice and tissue specimens from two patients with intraductal papillary adenoma of the pancreas by polymerase chain reaction-single-strand conformation polymorphism analysis and direct sequencing and found point mutations of p53 gene resulting in amino acid substitutions in exons 6 and 8. Thus, p53 gene mutation may be an early event in the neoplastic process of some pancreatic intraductal tumors and may play an important role in tumorigenesis.
关于人类胰腺良性导管内肿瘤中p53基因突变尚无报告。我们通过聚合酶链反应-单链构象多态性分析和直接测序检查了两名胰腺导管内乳头状腺瘤患者的胰液和组织标本，发现p53基因点突变导致外显子6和8中的氨基酸替换。因此，p53基因突变可能是某些胰腺导管内肿瘤肿瘤发生过程中的早期事件，并且可能在肿瘤发生中起重要作用。
