Sobiech K A, Szewczuk A
Arch Immunol Ther Exp (Warsz). 1976;24(3):451-8.
Gamma-Glutamyl transpeptidase activity in guinea pig intestine was tested toward 8 monoglutamyl and 4 diglutamyl substrates. Distinct differences in specificity and activity related to ontogenetic development were noted. A mixture of L-serine and borate inhibited specifically gamma-glutamyl transpeptidase activity of homogenates and accumulation of naphthylamine and 14C-substances in slices of intestine incubated with gamma-L-14C-glutamyl-alpha-naphthylamide. The same mixture, administered per os together with 14C-gamma-glutamyl substrate, specifically inhibited urinary excretion of 14C-substance, but had no effect on the rate of excretion of glycine, L-glutamic acid or L-pyroglutamic acid.
对豚鼠肠道中的γ-谷氨酰转肽酶活性进行了针对8种单谷氨酰和4种双谷氨酰底物的测试。注意到在特异性和与个体发育相关的活性方面存在明显差异。L-丝氨酸和硼酸盐的混合物特异性抑制匀浆的γ-谷氨酰转肽酶活性以及与γ-L-14C-谷氨酰-α-萘胺一起孵育的肠切片中萘胺和14C物质的积累。相同的混合物与14C-γ-谷氨酰底物一起经口给药,特异性抑制14C物质的尿排泄,但对甘氨酸、L-谷氨酸或L-焦谷氨酸的排泄速率没有影响。