斯堪的纳维亚慢性酒精中毒患者中酪氨酸羟化酶和多巴胺D4受体的等位基因分布

Tyrosine hydroxylase and dopamine D4 receptor allelic distribution in Scandinavian chronic alcoholics.

作者信息

Geijer T, Jönsson E, Neiman J, Persson M L, Brené S, Gyllander A, Sedvall G, Rydberg U, Wasserman D, Terenius L

机构信息

Department of Clinical Neuroscience, Huddinge University Hospital, Stockholm, Sweden.

出版信息

Alcohol Clin Exp Res. 1997 Feb;21(1):35-9.

PMID:9046370

Abstract

Associations of polymorphic genetic markers at the tyrosine hydroxylase (TH) and dopamine D4 receptor (DRD4) loci were examined in Scandinavian chronic alcoholics (n = 72) and control subjects (n = 67). Patients were divided into subgroups with regard to the presence of parental alcoholism and age of onset. Neither the TH nor the DRD4 allele distributions were significantly different when alcoholic samples were compared with control subjects. However, a tendency to high prevalence for 1 of the 5 TH alleles assayed (TH-K3) was observed in a subsample of 44 alcoholics characterized by late onset when compared with control subjects (27.3% vs. 10.6%, p = 0.041). Results suggest that no major influence on alcoholism is exerted through genes associated with the DRD4 or TH allelic markers examined.

摘要

在斯堪的纳维亚慢性酒精中毒患者（n = 72）和对照受试者（n = 67）中，研究了酪氨酸羟化酶（TH）和多巴胺D4受体（DRD4）基因座上多态性遗传标记的关联。根据父母是否酗酒和发病年龄，将患者分为亚组。当将酒精中毒样本与对照受试者进行比较时，TH和DRD4等位基因分布均无显著差异。然而，在44名以晚发为特征的酒精中毒患者亚样本中，与对照受试者相比，所检测的5个TH等位基因中的1个（TH-K3）出现高流行率的趋势（27.3%对10.6%，p = 0.041）。结果表明，所检测的与DRD4或TH等位基因标记相关的基因对酒精中毒没有重大影响。