Watanabe Y
Department of Surgery (1), Kanazawa University School of Medicine, Japan.
Nihon Geka Gakkai Zasshi. 1997 Jan;98(1):16-25.
In 1933, Graham successfully performed simple pneumonectomy for lung cancer. Since then, there has been great progress in surgical procedures such as anatomical lung resection, radical lung resection, combined resection of adjacent organs, bronchoplastic surgery and extensive lymph node dissection. Surgical mortality was over 20% in the early years. However, it has currently decreased to a few percent. According to a multi-institutional data analyzed by Ginsberg (1983), the modern 30-day surgical mortality is 3.7% overall (6.2% for pneumonectomy and 2.9% for lobectomy). The long-term survival rate for resected lung cancer patients has improved remarkably in recent years. The reported five-year survival rates of stage I non small cell cancer range between 60% and 85%, and those of stage II cancer range between 20% and 40%. Among stage IIIA cases, the optimal surgical outcome was shown in the group undergoing chest wall resection for T3N0M0 disease. However, the results of N2 disease generally show a poor surgical outcome. Therefore, trials of induction therapy are being done at many institutes. The surgical results of bronchoplastic surgery have markedly improved in recent years, especially among the group undergoing sleeve lobectomy. Stage I small cell carcinoma shows excellent surgical result with the aid of pre-or postoperative adjuvant chemotherapy with or without radiotherapy.
1933年,格雷厄姆成功地为肺癌患者实施了单纯肺切除术。从那时起,在诸如解剖性肺切除术、根治性肺切除术、相邻器官联合切除术、支气管成形术和广泛淋巴结清扫术等外科手术方面取得了巨大进展。早年手术死亡率超过20%。然而,目前已降至百分之几。根据金斯伯格(1983年)分析的多机构数据,现代30天手术死亡率总体为3.7%(肺切除术为6.2%,肺叶切除术为2.9%)。近年来,接受手术的肺癌患者的长期生存率有了显著提高。报道的I期非小细胞癌五年生存率在60%至85%之间,II期癌的五年生存率在20%至40%之间。在IIIA期病例中,对于T3N0M0疾病行胸壁切除术的组显示出最佳手术结果。然而,N2疾病的手术结果总体较差。因此,许多机构正在进行诱导治疗试验。近年来,支气管成形术的手术结果有了显著改善,尤其是在接受袖状肺叶切除术的组中。借助术前或术后辅助化疗(有无放疗),I期小细胞癌显示出优异的手术结果。