Watson A
Department of Dermatology, Royal Newcastle Hospital, New South Wales, Australia.
Australas J Dermatol. 1997 Feb;38(1):9-11. doi: 10.1111/j.1440-0960.1997.tb01090.x.
Phototherapy for mycosis fungoides is reviewed with particular emphasis on PUVA (psoralen ultraviolet A-range) therapy and its combination with other topical and systemic treatments. PUVA therapy has the advantages of being available in all major centres, is simple to administer, relatively inexpensive and has relatively low toxicity. Medium-term results suggest that PUVA is as effective as any of the other topical therapies for stage I disease. Its combination with alpha-interferon produces significant benefit in stage II or more advanced disease. Long-term non-melanoma skin cancer is increased with PUVA and combination PUVA usage, but melanoma is not increased. Its long-term position in comparison to other therapies with regard to morbidity, mortality and quality of life needs further evaluation.
对蕈样肉芽肿的光疗进行了综述，特别强调了补骨脂素紫外线A光疗法（PUVA）及其与其他局部和全身治疗方法的联合应用。PUVA疗法具有在所有主要医疗中心均可使用、易于实施、相对便宜且毒性相对较低的优点。中期结果表明，PUVA对I期疾病的疗效与任何其他局部疗法相当。它与α-干扰素联合应用对II期或更晚期疾病有显著疗效。长期使用PUVA及联合使用PUVA会增加非黑素瘤皮肤癌的发病率，但不会增加黑色素瘤的发病率。与其他疗法相比，其在发病率、死亡率和生活质量方面的长期地位需要进一步评估。
