Skyler J S
Division of Endocrinology, University of Miami School of Medicine, FL 33136, USA.
Postgrad Med. 1997 Feb;101(2):85-90, 92-4, 96. doi: 10.3810/pgm.1997.02.159.
Insulin therapy can control glucose levels in patients with type II diabetes. Because of insulin resistance, high doses may be required initially to attain satisfactory control; however, also because of insulin resistance, hypoglycemia with insulin therapy is much less common among patients with type II diabetes than among those with type I diabetes. Insulin therapy need not be permanent. In some cases, temporary worsening of disease is the result of glucose toxicity and insulin can be discontinued or doses reduced when disease severity subsides. On the other hand, beta-cell failure is progressive, and with long duration of diabetes, permanent insulin therapy may be necessary to achieve satisfactory glucose control.
胰岛素治疗可控制II型糖尿病患者的血糖水平。由于存在胰岛素抵抗，最初可能需要高剂量才能达到满意的控制效果；然而，同样由于胰岛素抵抗，与I型糖尿病患者相比，II型糖尿病患者接受胰岛素治疗时发生低血糖的情况要少得多。胰岛素治疗不一定是永久性的。在某些情况下，疾病的暂时恶化是葡萄糖毒性的结果，当疾病严重程度减轻时，可停用胰岛素或减少剂量。另一方面，β细胞功能衰竭是进行性的，随着糖尿病病程延长，可能需要长期使用胰岛素治疗才能实现满意的血糖控制。
