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The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity.

作者信息

Tedder T F, Inaoki M, Sato S

机构信息

Department of Immunology, Duke University Medical Center, Durham, North Carolina 27710, USA.

出版信息

Immunity. 1997 Feb;6(2):107-18. doi: 10.1016/s1074-7613(00)80418-5.

DOI:10.1016/s1074-7613(00)80418-5
PMID:9047233
Abstract
摘要

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The CD19-CD21 complex regulates signal transduction thresholds governing humoral immunity and autoimmunity.CD19 - CD21复合物调节控制体液免疫和自身免疫的信号转导阈值。
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Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement.补体成分C3d-抗原复合物在小鼠中可增强或抑制B淋巴细胞活化和体液免疫，这取决于CD21/CD19复合物的结合程度。
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CD19-CD21 complex regulates an intrinsic Src family kinase amplification loop that links innate immunity with B-lymphocyte intracellular calcium responses.CD19 - CD21复合物调节一种内在的Src家族激酶放大环，该环将先天免疫与B淋巴细胞细胞内钙反应联系起来。
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CD19 is a central response regulator of B lymphocyte signaling thresholds governing autoimmunity.
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CD19 can regulate B lymphocyte signal transduction independent of complement activation.CD19可独立于补体激活调节B淋巴细胞信号转导。
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Role of the CD19 and CD21/35 receptor complex in innate immunity, host defense and autoimmunity.CD19与CD21/35受体复合物在固有免疫、宿主防御及自身免疫中的作用
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Regulation of B lymphocyte responses to foreign and self-antigens by the CD19/CD21 complex.CD19/CD21复合物对B淋巴细胞对外源和自身抗原反应的调节
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CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression.CD21/35通过一条不依赖补体但依赖CD19的途径促进对肺炎链球菌的保护性免疫，该途径调节程序性死亡受体1（PD-1）的表达。
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CD21 and CD19 deficiency: Two defects in the same complex leading to different disease modalities.CD21和CD19缺陷：同一复合体中的两种缺陷导致不同的疾病形式。
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The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system.B淋巴细胞的CD19-CD21信号转导复合物调节健康与自身免疫性疾病之间的平衡：以系统性硬化症作为模型系统。
Curr Dir Autoimmun. 2005;8:55-90. doi: 10.1159/000082087.

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