Campman S C, Fajardo M A, Rippon M B, Kraegel S A, Ruebner B H
Department of Pathology, University of California, Davis Medical Center, Sacramento 95817, USA.
J Surg Oncol. 1997 Feb;64(2):159-62. doi: 10.1002/(sici)1096-9098(199702)64:2<159::aid-jso13>3.0.co;2-1.
Approximately 500 cystic neoplasms of the pancreas have been reported, and among these the mucinous pancreatic cystadenomas are known to have malignant potential. We report a rare case of a mucinous cystadenoma containing adenosquamous carcinoma.
We studied the histochemical and immunohistochemical staining characteristics of the tumor by staining with hematoxylin/eosin, Alcian Blue/Periodic Acid Schiff, and with immunoperoxidase-labelled antibodies against carcinoembryonic antigen, epithelial membrane antigen, low and high molecular weight cytokeratins, the proliferation antigen Ki-67, and the tumor suppressor antigen p-53. The K-ras oncogene was analyzed by direct sequencing.
This case illustrates the usual presentation and features of this unusual tumor-a middle aged woman with abdominal pain and no history of alcohol abuse or abdominal trauma. The mucinous cystic tumor of her pancreas was composed predominantly of benign epithelium with areas of a malignant component that were identified by thorough sampling.
We discuss the nomenclature of these neoplasms and suggest that continuing efforts to subclassify mucinous cystic pancreatic tumors histologically may not be necessary, since the tumors are all histologically similar and are malignant or have malignant potential, and for all, treatment should include resection.
据报道，胰腺囊性肿瘤约有500例，其中黏液性胰腺囊腺瘤已知具有恶变潜能。我们报告一例罕见的含有腺鳞癌的黏液性囊腺瘤病例。
我们通过苏木精/伊红染色、阿尔辛蓝/过碘酸希夫染色以及用抗癌胚抗原、上皮膜抗原、低分子量和高分子量细胞角蛋白、增殖抗原Ki-67和肿瘤抑制抗原p-53的免疫过氧化物酶标记抗体进行免疫组织化学染色，研究了肿瘤的组织化学和免疫组织化学染色特征。通过直接测序分析K-ras癌基因。
该病例说明了这种罕见肿瘤的常见表现和特征——一名中年女性，有腹痛症状，无酗酒或腹部外伤史。她胰腺的黏液性囊性肿瘤主要由良性上皮组成，通过全面取材发现了恶性成分区域。
我们讨论了这些肿瘤的命名，并建议不必继续努力对黏液性胰腺囊性肿瘤进行组织学亚分类，因为这些肿瘤在组织学上都相似，都是恶性的或具有恶变潜能，并且对所有病例而言，治疗都应包括手术切除。
