Fiber J M, Swann J M
Institute of Animal Behavior, Department of Biological Sciences, Rutgers University, Newark, New Jersey 07102, USA.
Horm Behav. 1996 Dec;30(4):455-73. doi: 10.1006/hbeh.1996.0050.
The results of the present study indicate that (1) pheromones differentially stimulate neurons in males and females within a pathway that regulates copulatory behavior; and (2) testosterone (T) differentially regulates these sex differences. Exposure to the pheromones in FHVS (female hamster vaginal secretions) induces Fos immunoreactivity (Fos-IR) in the posterior subdivision of the medial nucleus of the amygdala (MeP) and the posteromedial subdivision of the bed nucleus of the stria terminalis (BNSTpm) of both sexes and stimulates the magnocellular subdivision of the medial preoptic nucleus (MPNmag) in males but not in females. Males also show more Fos in the MeP and BNSTpm than females. In the absence of T, gonadectomized males show greater FHVS-stimulated Fos-IR in the BNSTpm and MeP than gonadectomized females. T in females eliminates the sex difference in these regions. Only T-treated males show FHVS-stimulated Fos-IR within the MPNmag, and T has no effect on FHVS-stimulated Fos-IR within MPNmag in females. Thus, T influences FHVS-stimulated Fos-IR in the BNSTpm and MeP of females and the MPNmag of males. T also increases investigation (sniffing and licking) of FHVS in both males and females, but increases copulatory responses only in males. Our results indicate that T in the adult hamster differentially influences neural and behavioral responses to pheromone exposure in males and females. T only partially accounts for observed sex differences, and it is likely that neural organization during development also plays a role in influencing responses to pheromones.
（1）在调节交配行为的通路中，信息素对雄性和雌性神经元的刺激存在差异；（2）睾酮（T）对这些性别差异具有不同的调节作用。暴露于雌性仓鼠阴道分泌物（FHVS）中的信息素会诱导两性杏仁核内侧核后部（MeP）和终纹床核后内侧部（BNSTpm）的Fos免疫反应性（Fos-IR），并刺激雄性内侧视前核大细胞部（MPNmag），而对雌性则无此作用。雄性在MeP和BNSTpm中的Fos表达也比雌性更多。在没有T的情况下，去势雄性在BNSTpm和MeP中表现出比去势雌性更强的FHVS刺激的Fos-IR。雌性体内的T消除了这些区域的性别差异。只有经T处理的雄性在MPNmag内表现出FHVS刺激的Fos-IR，而T对雌性MPNmag内FHVS刺激的Fos-IR没有影响。因此，T影响雌性BNSTpm和MeP以及雄性MPNmag中FHVS刺激的Fos-IR。T还增加了雄性和雌性对FHVS的探究行为（嗅闻和舔舐），但仅增加了雄性的交配反应。我们的结果表明，成年仓鼠体内的T对雄性和雌性信息素暴露的神经和行为反应有不同影响。T只能部分解释观察到的性别差异，发育过程中的神经组织可能也在影响对信息素的反应中发挥作用。
