在醋酸亮丙瑞林基础上加用醋酸炔诺酮进行卵巢抑制对卵巢刺激无不良影响。
The addition of norethindrone acetate to leuprolide acetate for ovarian suppression has no adverse effect on ovarian stimulation.
作者信息
Ditkoff E C, Prosser R, Zimmermann R C, Lindheim S, Sauer M V
机构信息
Department of Obstetrics and Gynecology, Columbia-Presbyterian Medical Center, Columbia University, New York, New York 10032, USA.
出版信息
J Assist Reprod Genet. 1997 Feb;14(2):92-6. doi: 10.1007/BF02765777.
PURPOSE
Our goal was to determine if the addition of norethindrone acetate (NETA) to leuprolide acetate (LA) has an adverse effect on controlled ovarian stimulation (COH) during in vitro fertilization (IVF).
METHODS
Forty-one consecutive patients undergoing COH and IVF were divided into two groups and evaluated. Group 1 consisted of 18 patients who did not become pregnant following two cycles (one of each protocol). Group 2 consisted of 23 patients who became clinically pregnant following one cycle from either protocol. The standard protocol consisted of LA (1 mg) injected subcutaneously from the first day of menses until day 8 or when ovarian suppression was evident, at which time the dose was halved and COH was initiated. The study protocol was identical except 10 mg of NETA was given orally with LA for the first 8 days. Ovarian stimulation was similar in each protocol.
RESULTS
No adverse effect on ovarian stimulation was evident on the addition of NETA to LA. No differences were noted in days of stimulation, peak estradiol (E2) level attained, peak E2-to-oocyte ratio, dosage of exogenous gonadotropins, number of aspirated oocytes, fertilization rate, or oocyte and preembryo quality.
CONCLUSIONS
The addition of NETA does not attenuate COH in women undergoing IVF.
目的
我们的目标是确定在醋酸亮丙瑞林（LA）中添加醋酸炔诺酮（NETA）是否会对体外受精（IVF）期间的控制性卵巢刺激（COH）产生不利影响。
方法
41例连续接受COH和IVF的患者被分为两组并进行评估。第1组由18例在两个周期（每个方案各一个周期）后未怀孕的患者组成。第2组由23例从任一方案的一个周期后临床妊娠的患者组成。标准方案包括从月经第一天开始皮下注射LA（1mg）直至第8天或卵巢抑制明显时，此时剂量减半并开始COH。研究方案相同，只是在前8天与LA一起口服10mg NETA。每个方案中的卵巢刺激相似。
结果
在LA中添加NETA对卵巢刺激没有明显的不利影响。在刺激天数、达到的雌二醇（E2）峰值水平、E2峰值与卵母细胞比率、外源性促性腺激素剂量、吸出的卵母细胞数量、受精率或卵母细胞和胚胎前质量方面没有发现差异。
结论
添加NETA不会减弱接受IVF的女性的COH。
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