Lassen M R, Borris L C
Department of Orthopedics, Hillerød Hospital, Denmark.
Orthopedics. 1997 Feb;20 Suppl:14-7.
Patients undergoing arthroplastic surgery of the lower limbs and those with multiple injuries have a high risk of thromboembolism. Enoxaparin is a highly effective antithrombotic drug that is well tolerated and without the need for monitoring. Numerous controlled trials in these patient groups have demonstrated enoxaparin to be at least as effective as heparin in reducing the occurrence of deep vein thrombosis while showing a tendency towards lower risk of bleeding complications; therefore, enoxaparin is recommended as thromboprophylaxis in patients undergoing major hip or knee surgery or suffering from multiple trauma.
接受下肢关节置换手术的患者以及多发伤患者发生血栓栓塞的风险很高。依诺肝素是一种高效抗血栓药物，耐受性良好且无需监测。在这些患者群体中进行的大量对照试验表明，依诺肝素在降低深静脉血栓形成发生率方面至少与肝素一样有效，同时出血并发症风险有降低趋势；因此，推荐依诺肝素用于接受大髋关节或膝关节手术或患有多发伤的患者进行血栓预防。
