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The interferon sensitivity determining region: all hepatitis C virus isolates are not the same.

作者信息

Herion D, Hoofnagle J H

出版信息

Hepatology. 1997 Mar;25(3):769-71. doi: 10.1002/hep.510250346.

DOI:10.1002/hep.510250346
PMID:9049233
Abstract
摘要

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引用本文的文献

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Mutations around interferon sensitivity-determining region: a pilot resistance report of hepatitis C virus 1b in a Hong Kong population.干扰素敏感性决定区周围的突变:香港人群中丙型肝炎病毒 1b 的耐药性初步报告。
World J Gastroenterol. 2011 Dec 28;17(48):5317-23. doi: 10.3748/wjg.v17.i48.5317.
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Genetic variability of hepatitis C virus before and after combined therapy of interferon plus ribavirin.干扰素联合利巴韦林治疗前后丙型肝炎病毒的基因变异性
PLoS One. 2008 Aug 26;3(8):e3058. doi: 10.1371/journal.pone.0003058.
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Replicative homeostasis III: implications for antiviral therapy and mechanisms of response and non-response.复制性稳态III:对抗病毒治疗的影响以及应答和无应答机制
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Sustained virological response in hepatitis C virus type 1b infected patients is predicted by the number of mutations within the NS5A-ISDR: a meta-analysis focused on geographical differences.通过NS5A-ISDR内的突变数量预测1b型丙型肝炎病毒感染患者的持续病毒学应答:一项关注地理差异的荟萃分析
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Hepatitis C virus nonstructural 5A protein induces interleukin-8, leading to partial inhibition of the interferon-induced antiviral response.丙型肝炎病毒非结构5A蛋白诱导白细胞介素-8,导致干扰素诱导的抗病毒反应部分受到抑制。
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