Agostini H T, Ryschkewitsch C F, Singer E J, Stoner G L
Laboratory of Experimental Neuropathology, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland 20892-4126, USA.
J Gen Virol. 1997 Mar;78 ( Pt 3):659-64. doi: 10.1099/0022-1317-78-3-659.
JC virus (JCV) causes the central demyelinating disease progressive multifocal leukoencephalopathy (PML). JCV strains excreted in the urine are distinguishable from those in PML tissue by the configuration of their regulatory region to the right of ori: the archetypal regulatory region, 267 nucleotides long, is rearranged in PML tissue by deletion and duplication. Within the coding region JCV shows variations as a result of virus evolution. Four major genotypes are distinguishable of which Type 1 is based in Europe and Type 2 in Asia. Here, the regulatory region rearrangements and the viral genotypes of 29 JCV strains from PML brain were determined. Rearrangement patterns and genotypes were not associated. In general, deletions occurred before duplications, but exceptions to this rule exist. Each configuration of the 29 rearranged regulatory regions was unique and could be derived directly from the non-rearranged, archetypal form.
JC病毒（JCV）可引发中枢脱髓鞘疾病——进行性多灶性白质脑病（PML）。通过其调控区在ori右侧的结构，可区分尿液中排出的JCV毒株与PML组织中的毒株：原型调控区长267个核苷酸，在PML组织中会因缺失和重复而发生重排。在编码区内，JCV会因病毒进化而出现变异。可区分出四种主要基因型，其中1型以欧洲为基地，2型以亚洲为基地。在此，对来自PML脑的29株JCV毒株的调控区重排和病毒基因型进行了测定。重排模式和基因型并无关联。一般而言，缺失发生在重复之前，但也存在此规则的例外情况。29个重排调控区的每种结构都是独特的，且可直接源自未重排的原型形式。
