酸性成纤维细胞生长因子对大鼠缺血再灌注诱导的心律失常的保护作用。
Protective effects of acidic fibroblast growth factor against cardiac arrhythmias induced by ischemia and reperfusion in rats.
作者信息
Cuevas P, Carceller F, Hernández-Madrid A, Cuevas B, Martínez-Coso V, Giménez-Gallego G
机构信息
Servicio de Histología, Hospital Ramón y Cajal, Madrid, Spain.
出版信息
Eur J Med Res. 1997 Jan;2(1):33-6.
An in vivo study has been conducted to evaluate the effect of acidic fibroblast growth factor (aFGF) on cardiac arrhythmias which occur in transient myocardial ischemia followed by reperfusion. In a rat model of myocardial ischemia and reperfusion, cardiac arrhythmias were assessed during the first three minutes of reperfusion. Systemic administration of 2.6 micrograms aFGF just before coronary recirculation resulted in a significant reduction in incidence and severity of ventricular extra beats (VEBs), ventricular tachycardia (VT) and ventricular fibrillation (VF), compared with control rats (VT incidence: 30% vs 80%, VF incidence: 10% vs 40%; episodes of VT: 4.1 +/- 0.34 vs 8.8 +/- 0.95; episodes of VF: 4.8 +/- 0.32 vs 11.5 +/- 1.47). Our results suggest a novel role for FGFs as potential antiarrhythmic agents.
已开展一项体内研究，以评估酸性成纤维细胞生长因子（aFGF）对短暂性心肌缺血后再灌注时发生的心律失常的影响。在心肌缺血再灌注大鼠模型中，于再灌注的前三分钟评估心律失常情况。与对照大鼠相比，在冠状动脉再循环前全身给予2.6微克aFGF可使室性早搏（VEB）、室性心动过速（VT）和室颤（VF）的发生率和严重程度显著降低（VT发生率：30%对80%，VF发生率：10%对40%；VT发作次数：4.1±0.34对8.8±0.95；VF发作次数：4.8±0.32对11.5±1.47）。我们的结果表明FGFs作为潜在抗心律失常药物具有新的作用。
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